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Main Ingredients

Following are the scientifically proven therapeutic agents—phytochemicals—possessed by Rye, and some of their therapeutic attributes:

Beta 1,3 glucan
In the June, 1996 edition of The Towsend Letter for Doctors, is found an article by Donald Carrow MD on Beta 1, 3 Glucan as a Primary Immune Activator Dr Carrow observes that ‘tong before the advent of the germ theory, our forefathers had observed that recovery from illnesses could be accomplished by host resistance. You could say that immunology preceded our discovery of microbiology and bacteriology”

Beta 1, 3 glucan is a poly-saccharide molecule consisting of purified glucose with a unique molecular structure that specifically bonds to receptor sites on macrophages. Research at Harvard University found that there are receptor sites for 7 different sugars (poly-saccharides) on the macrophage membranes. Unlike pure glucose (white sugar) that suppresses the phagocytic activity of immune cells, Beta 1, 3 glucan activates macrophage activity and sets off a cascade of events which stimulates immune function in several areas. These include increases in complement production, serum cytokines, interluken I, interluken II and interferon. By this cascade of events, Beta 1, 3 glucan increases non-specific immunity against all infectious diseases including cancer Peter Mansell, MD, reported that subcutaneous nodules of malignant melanoma injected with Beta Glucan resolved within a few days (Beta 1, 3 Glucan, an Immune System Activator found in Baker's Yeast and young Rye plants, enhances cell mediated immunity and non-specific immunity — inactivates HHV-6. Positive Health News [USA] 1996).

Phyto-oestrogens
Phyto-oestrogens are oestrogen-like compounds endogenously produced (developed within an organism) by intestinal bacterial metabolism on precursors found in a variety of seeds and vegetables. There is evidence that the startling increase in the hormone-driven cancers over the past two decades is due to increasing exposure to environmental pollutants called pseudo-oestrogens, or “false oestrogens.” These potent oestrogen mimics are found in many common pesticides, plastics, and other industrial chemicals and can wreak havoc on your body's delicate hormone balance. Because of their chemical similarity to oestrogen, phyto-oestrogens bind to the body's oestrogen receptors and block the effects of excessive oestrogen—whether from synthetic or natural sources.

Phyto-oestrogens represent a family of plant compounds that have been shown to have both oestrogenic and anti-oestrogenic properties. They contain isoflavones, which are weak oestrogen-like constituents that act as adaptogens. Here's how an adaptogen works. If you have an excessive amount of oestrogen, these substances help block the oestrogen from entering oestrogen receptor sites. If there is not enough oestrogen, they fill the gap. This is what is meant by the adaptogenic phenomenon (Journal of Clinical Endocrinology & Metabolism 1 998;Jul;83(7):2223-35).

Example of an adaptogen: A good chromium supplement is “adaptogenic” because it is helpful for those with high blood sugar (diabetics), and for those with low blood sugar (hypoglycemics).

Experts have long noted that Asian women on traditional diets, rich in soy products such as tofu, seem to have very little trouble with menopause symptoms, and have a low incidence of breast cancer This now begins to make sense as soy products contain high levels of these phyto-oestrogens. Grains such as Rye give rise to substances called lignans. Lignans and isoflavones are plant oestrogens derived from Rye, soy beans and other legumes.

Matairesinol
Matairesinol is a lignan commonly found in combination with isoflavines which possess many of the same activities as isoflavones. Lignans are alcohols that derive from the same biosynthetic pathway as lignans- polysaccharides that combine with cellulose to form the cell wall of plants.

Anti-leukemic cell efficacy of 28 naturally occurring and synthetic flavonoids and 11 naturally occurring lignans on human promyelocytic leukemic cell line HL-60 were examined using MTT assay methods. Differences between anti-cell-proliferative activity and cytotoxicity of these compounds were compared with those of 4 clinical anti-cancer agents. Eight of the 28 flavonoids and 4 of the 11 lignans showed considerable suppressive effects on HL-60 cell growth with IC(50)s ranging from 10-940 ng/mL Among these compounds, Genistein, honokiol, machilin A, Matairesinol and arctigenin had the strongest effects with IC(50)s less than 100 ng/mL which were almost equivalent to the effects of current anti-cancer agents. The lignans and Genistein were strongly suppressive against incorporations of [H-3]thymidine, [H-3]uridine and [H-3]leucine into HL-60 cells. These results showed that some of the naturally occurring flavonoids and lignans inhibited HL-60 cell growth with a non-toxic mechanism, possibly via cessation of DNA, RNA, and/or protein synthesis of the leukemic cells (Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cells; Hirano, T., M. Gotoh, et al., Life Science 55 [13]: 1061-1069;1994).

Genistein
Genistein is a phyto-oestrogen and the more studied of the isoflavone group.

Genistein really stands out as the ingredient that's most active in stopping cancer growth and angiogenesis (Zhou and Lee, Journal Nat.Cancer Institute, 90, 381 [1998]).

The CCAAT binding factor (protein) normally binds to an important genetic “motif' in DNA and triggers the stress genes. Genistein adds phosphorous to the binding factor neutralising it before the switch is tripped so the cancer cell starves, withers and dies (New Scientist, 2125, 14 [1998]).

Isoflavones (genistein) may improve endothelial functioning and attenuate events leading to both lesion and thrombus formation (Nutritional Reviews 1 998;Aug;56[8];231-5).

Daidzein
Daidzein is a phyto-oestrogen and falls into the same group of isoflavones as Genistein, which are compounds responsible for reducing cancerous growth.

Squalene
Squalene is found in oils, including olive oils and in some plants such as Rye, and in significant quantities in shark oil.

It is proposed that the high Squalene content of olive oil, as compared to other human foods, is a major factor in the cancer risk-reducing effect of olive oil. Experiments suggest a tumour-inhibiting role for Squalene (Cancer Epidemiology Biomarkers Prevention 1997;Dec;6[1 2];1 101-3).

In humans, about 60% of the dietary Squalene is absorbed and transported to the tissues where it is found most abundantly in the skin and appears to function as a singlet radical quencher, protecting skin from harmful UV rays and other sources of radical formation. Squalene also plays an important role in the body's production of cholesterol, and therefore in heart health.

Combination therapy of a cholesterol-lowering drug with Squalene significantly reduced total cholesterol and low density lipoprotein (LDL) cholesterol and increased high density lipoprotein (HDL) cholesterol to a greater extent than the drug (Journal of Clinical Pharmacology 1 996;May;36[5];422-7).

Co-enzyme Q1O
Co-enzymes are compounds derived from food whereas enzymes are protein molecules made in the body. Co-enzymes are much smaller than normal enzymes and being minute molecules they are not rendered inactive through digestion but are easily absorbed into the bloodstream. Co-enzyme Q10 acts as an electron donor to the electron transport chain of cellular respiration. Thus, Co-enzyme Q10's primary function is to aid in the generation of energy within the cell. Newspapers recently reported the results of medical research conducted in Melbourne, Australia, in which Co-enzyme Q10 "made old hearts young again".

Dr Franklin Rosenfeldt, the head of cardiac surgical research at the Baker Institute, reported that with Q10 treatments, hearts of people over seventy years of age perform as well as those of thirty-year-olds. Dr Rosenfeldt found that free radicals added strain to an elderly patient's heart, especially during open heart surgery. Free radicals are unpaired negatively charged electrons that roam free trying to balance their electrical charge and immediately begin to chop holes in cell membranes as they grab positive charges. Dr Rosenfeldt found that Co-enzyme Q10 improves the way cells convert oxygen and food to energy, strengthening the heart so that it beats more strongly. At the same time, Co-enzyme Q10 prevents production of oxygen free radicals due to efficient controlled use of oxygen and hydrogen electrons which then ensures that cellular anti-oxidants have less free radicals to negate. His research met with wide acclaim when presented at an international conference in the USA.

Phyto-sterols and Sterolins
Sitosterols and sterolins are phyto-chemicals. They are plant fats chemically similar to the animal fat cholesterol but totally different in biological functions. They are bound to the fibres of the Rye plant. Sterols always exist in combination with their glucosides. Available scientific evidence indicates that sterols and sterolins modulate the functions of the immune system T-cells by enhancing their cellular division and secretion of important soluble factors called lymphokine-activated killer cells (LAKs). If the "correct" lymphokines could be secreted by the T-cells, then one should be able to correct the disease process and the disease would be alleviated. In other words, the sterols-sterolins mixture treats the underlying causes and not the symptoms. Also, the activity of the cytotoxic cells is greatly promoted in the presence of the sterols-sterolins mixture. These activities are of utmost importance in fighting off viral diseases or diseases involving bacteria which live inside cells - such as Tuberculosis.

Weight gain was significantly greater in the sitosterol group than the placebo group. Change in lymphocyte counts from baseline was significantly higher in the sitosterol group as was the increase in eosinophil counts. The study has shown significantly improved weight gain and higher lymphocyte and eosinophil counts in pulmonary tuberculosis patients receiving sitosterols in addition to an efficacious anti-tuberculosis regimen (International Journal of Tuberculosis & Lung Disease, 1 [6)518-22,1997 Dec).

The phyto-sterols, beta-sitosterol, and its glucoside enhance the in- vitro proliferative response of T-cells stimulated by sub-optimal concentrations of phyto-haemagglutinin. . .. NK-cell activity was also increased by beta-sitosterol and its glucoside (International Journal of lmmunopharmacology, 1 8[1 2]:693-700, 1996 Dec).

The following are also present in Oralmat

Minerals
Calcium, copper, iron, manganese, magnesium, nitrogen, phosphorus, potassium, sodium, and zinc.

Vitamins
B-complex vitamins choline and pantothenic acid, Beta-carotene, B1 thiamin, B2 riboflavin, B3 niacin, C ascorbic acid, biotin and folic acid. Vitamins B complex serves as co-factors for enzyme systems. Pantothenic and folic acids are required for antibody formation and white cell formation. Thiamin, niacin, riboflavin, and pantothenic acid are essential to the derivation of energy from glycolysis and the tricarboxylic acid cycle.

In her book Let's Get Well, nutritionist Adelle Davis writes "vitamins B6, C and Pantothenic Acid each have anti-histamine actions, and lack of any one allows certain blood cells (eosinophils) to increase abnormally which is characteristic of allergies".

Proteins (amino acids)
Alanine, arginine, aspartic, cystine, glutamic, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine and valine.

Available scientific evidence indicates that arginine and lysine work together with glutamine, formed from glutamic acid, to stimulate the endocrine system's pituitary gland in the brain to release human growth hormones, thereby stimulating the immune system and producing highly activated white blood cells. Also, arginine is a sought after item because of its well known ability to burn fat while building muscle. Cystine, working together with the vitamin pantothenic acid, have clinically demonstrated their positive effects for patients suffering osteo-arthritis and rheumatoid arthritis. Topical application of Cystine increases the rate of healing by up to 50 per cent in conditions such as superficial wounds, varicose ulcers, diabetic ulcers, burns and dermal conditions, and increases the formation and maturation of collagen.

Fatty acids
Arachidic, capric, erucic, lauric, linoleic, linolenic, myristic, oleic, palmitic, stearic and zoomaric. Linoleic and linolenic acids serve as building blocks for prostaglandins—inflammatory mediators that promote dilation of small blood vessels—that regulate cellular metabolism, inflammation and circulation.

Enzymes
A treasure chest of enzymes. Enzymes are proteins that act as biological catalysts to speed up chemical reactions.

Very enlightening! It is little wonder that Rye's constituent of immune activators gives rise to stimulation and amplification of the body's own immune responses. The abovementioned individual chemicals (possessed by Rye sprouts) have been researched independently for decades and the results are indeed profound and encouraging for medical science and the future of medicine.

Although these life-enhancing plant chemicals may exist in some raw foods, the majority can be lost or destroyed by freezing of vegetables, heat from cooking, or removed in food processing. They are not lost or destroyed in Oralmat or Acno Rye-based products. The patented extraction and processing methods ensure their biological integrity is retained. And, to have all of these phyto-chemicals present in one compound is an added bonanza! Conceived of and brought forth in a single compound, the myriad of different chemicals work together synergistically to produce an effect greater than the sum of their individual effects. The body and the immune system are the "rewardees" of this bonanza.

The Power of Synergy
The immune system is a perfect example of synergy. The immune system is an intricate collection of specialised cells, organs and structures, that when communicating and working together as a whole - in synergy - transforms into an incredible defence system that identifies, tags and destroys foreign invaders in the body to produce health. It is health that is greater than the sum of its individual parts. Disease liberated back to health - that's the power of synergy!

Chemically speaking, Ryegrass is a combination of complex forms of proteins, carbohydrates, vitamins, minerals and essential oils. It is its "chemical structures and synergistic actions" that produce significant therapeutic actions. That is, the resulting therapeutic actions are greater than the sum of the individual chemical effects. It is vital to understand that with many natural substances, such as bee pollen and Rye, the entire chemical makeup of the substance creates a synergistic unit. The proteins, carbohydrates, minerals and so on found in Rye complement and augment each other We should never consider improving the therapeutic qualities that Rye possesses through extraction of its individual chemical elements for use in isolated form, or producing synthetic drugs to mimic its qualities. The power remains in the synergy of the whole!

Metabolism of Rye and Natural Plant Chemicals

The Chemical Composition of Rye and Metabolism
The constituent of chemicals possessed by Rye is outstanding, supplying a variety of functional foods and nutrients for the body to use as building blocks. The body treats natural plant chemicals as endogenous substances and, through digestion, utilises them to produce all sorts of substances for the body's ongoing needs. During that same process, specific parts of the body such as the adrenal glands and endocrine reticulum, convert precursors found in the Rye extract to hormones, glyco-proteins and other biochemical compounds that it needs. The body does so with exquisite exactness of amount and timing to produce just what the body needs when the body needs it. There is no guessing as to dose, no fear of overdose, no wondering about the best time to take it, and no potential toxicity. Therefore, there is no concern about the long-term effects. This metabolic process applies to natural live essences derived from Rye and other nutritious plants. The process does not apply to synthetic substances - such as drugs and antibiotics - which the body treats as exogenous substances. It is well known that synthetic substances arouse concern in relation to toxicity, overdose and long-term effects. The long-term and short-term effects of Oralmat Rye-based products are their ability to normalise (bring into a healthy state) the body's cells, vessels, organs and blood when diseased.